Decanoyl-RVKR-CMK

Name: Decanoyl-RVKR-CMK
Brand: Tocris Bioscience
SKU: 3501

Tocris Bioscience, part of Bio-Techne | Catalog # 3501

Citations (25)

COA / SDS

Subtilisin/Kex2p-like proprotein convertase inhibitor

Key Product Details

Description:	Subtilisin/Kex2p-like proprotein convertase inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	744.42

View Full Technical Details for Decanoyl-RVKR-CMK

Technical Data
Citations

Biological Activity for Decanoyl-RVKR-CMK

Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Inhibits cleavage of glycoprotein B of human cytomegalovirus. Also inhibits cleavage of SARS-CoV-2 spike protein by furin and blocks viral cell entry (IC₅₀ = 57 nM in plaque reduction assay).

Technical Data for Decanoyl-RVKR-CMK

M. Wt	744.42
Formula	C₃₄H₆₆ClN₁₁O₅
Single Letter Sequence	RVKR (Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	150113-99-8
PubChem ID	9962075
InChi Key	NHBJTTGFHCHQHS-VZTVMPNDSA-N
Smiles	[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Decanoyl-RVKR-CMK

Solubility

Soluble to 1mg/ml in water

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References for Decanoyl-RVKR-CMK

References are publications that support the biological activity of the product.

Vey Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediatedby the human endoprotease furin. Virology 1995 PMID: 7726996
Cheng Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 2020 PMID: 33007239
Tian and Jianhua Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 2010 PMID: 20151049
Denault Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 1995 PMID: 8587448
Garcia A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 2005 PMID: 16221685