Deltarasin

Name: Deltarasin
Brand: Tocris Bioscience
SKU: 5424

Tocris Bioscience, part of Bio-Techne | Catalog # 5424

Citations (3)

COA / SDS

High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Key Product Details

Description:	High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Chemical Name:	2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	713.14

View Full Technical Details for Deltarasin

Technical Data
Citations

Biological Activity for Deltarasin

Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor (K_d = 41 nM); binds to PDEδ. Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

Compound Libraries for Deltarasin

Deltarasin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Deltarasin

M. Wt	713.14
Formula	C₄₀H₃₇N₅O.3HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1440898-82-7
PubChem ID	91826089
InChi Key	NCIOVAYUMQEQEU-VKZSUDIWSA-N
Smiles	C12=CC=CC=C1N=C(C4=CC=C(OC[C@H]([C@H]8CCNCC8)N5C(C7=CC=CC=C7)=NC6=C5C=CC=C6)C=C4)N2CC3=CC=CC=C3.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deltarasin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	71.31	100
	DMSO	71.31	100

Preparing Stock Solutions for Deltarasin

The following data is based on the product molecular weight 713.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.01 mL	14.02 mL
5 mM	0.28 mL	1.40 mL	2.80 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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References for Deltarasin

References are publications that support the biological activity of the product.

Zimmermann Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site. J.Med.Chem. 2014 PMID: 24884780
Zimmermann Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 2013 PMID: 23698361