Demethylasterriquinone B1

Name: Demethylasterriquinone B1
Brand: Tocris Bioscience
SKU: 1819
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1819

(1)

Citations (2)

COA / SDS

Selective insulin RTK activator

Key Product Details

Description:	Selective insulin RTK activator
Alternative Names:	DAQ B1,L-783,281,DMAQ-B1
Chemical Name:	2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
Purity:	≥95% (HPLC)
Molecular Weight:	506.59

View Full Technical Details for Demethylasterriquinone B1

Technical Data
Citations / Reviews (1)

Biological Activity for Demethylasterriquinone B1

Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC₅₀ values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Technical Data for Demethylasterriquinone B1

M. Wt	506.59
Formula	C₃₂H₃₀N₂O₄
Storage	Desiccate at -20°C
Purity	≥95% (HPLC)
CAS Number	78860-34-1
PubChem ID	3013166
InChi Key	XMGNJVXBPZAETK-UHFFFAOYSA-N
Smiles	CC(C)=CCC1=C2NC=C(C2=CC=C1)C1=C(O)C(=O)C(C2=C(NC3=CC=CC=C23)C(C)(C)C=C)=C(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Demethylasterriquinone B1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.66	100

Preparing Stock Solutions for Demethylasterriquinone B1

The following data is based on the product molecular weight 506.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for Demethylasterriquinone B1

References are publications that support the biological activity of the product.

Wilkie The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 2001 PMID: 11553687
Webster Signaling effects of demethylasterriquinone B1, a selective Ins receptor modulator. Chembiochem 2003 PMID: 12740809
Salituro Discovery of a small molecule Ins receptor activator. Recent Prog.Horm.Res. 2001 PMID: 11237209
Weber A novel Ins mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 2000 PMID: 11107083
Kim Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the Ins mimic demethylasterriquinone B1. J.Med.Chem. 2007 PMID: 17595071