Deoxynivalenol

Name: Deoxynivalenol
Brand: Tocris Bioscience
SKU: 3976

Tocris Bioscience, part of Bio-Techne | Catalog # 3976

Citations (3)

COA / SDS

Mycotoxin; potent protein synthesis inhibitor

Key Product Details

Description:	Mycotoxin; potent protein synthesis inhibitor
Alternative Names:	DON,Vomitoxin
Chemical Name:	3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Purity:	≥98% (HPLC)
Molecular Weight:	296.32

View Full Technical Details for Deoxynivalenol

Technical Data
Citations

Biological Activity for Deoxynivalenol

Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Technical Data for Deoxynivalenol

M. Wt	296.32
Formula	C₁₅H₂₀O₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	51481-10-8
PubChem ID	40024
InChi Key	LINOMUASTDIRTM-QGRHZQQGSA-N
Smiles	CC1=C[C@]2([H])[C@]([C@@](C)(C[C@H]4O)[C@]3(CO3)[C@@]([H])4O2)(CO)[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deoxynivalenol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	8.89	30

Preparing Stock Solutions for Deoxynivalenol

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	11.25 mL	56.25 mL	112.49 mL
1.5 mM	2.25 mL	11.25 mL	22.50 mL
3 mM	1.12 mL	5.62 mL	11.25 mL
15 mM	0.22 mL	1.12 mL	2.25 mL

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References for Deoxynivalenol

References are publications that support the biological activity of the product.

Shi Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 2009 PMID: 19336499
Krishnaswamy Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 2010 PMID: 20347963
Bae and Pestka Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 2008 PMID: 18502741