Dexrazoxane hydrochloride

Name: Dexrazoxane hydrochloride
Brand: Tocris Bioscience
SKU: 3857

Tocris Bioscience, part of Bio-Techne | Catalog # 3857

Citations (2)

COA / SDS

Topoisomerase II inhibitor

Key Product Details

Description:	Topoisomerase II inhibitor
Alternative Names:	ICRF-187
Chemical Name:	4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	304.73

View Full Technical Details for Dexrazoxane hydrochloride

Technical Data
Citations

Biological Activity for Dexrazoxane hydrochloride

Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Technical Data for Dexrazoxane hydrochloride

M. Wt	304.73
Formula	C₁₁H₁₆N₄O₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1263283-43-7
PubChem ID	6918223
InChi Key	BIFMNMPSIYHKDN-FJXQXJEOSA-N
Smiles	C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dexrazoxane hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	30.47	100
	DMSO	30.47	100

Preparing Stock Solutions for Dexrazoxane hydrochloride

The following data is based on the product molecular weight 304.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.28 mL	16.41 mL	32.82 mL
5 mM	0.66 mL	3.28 mL	6.56 mL
10 mM	0.33 mL	1.64 mL	3.28 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for Dexrazoxane hydrochloride

References are publications that support the biological activity of the product.

Spallarossa Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz. J.Pharmacol.Exp.Ther. 2010 PMID: 19841470
Classen Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci.
Lebrecht Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 2007 PMID: 17519947