(±)-ADX 71743

Name: (±)-ADX 71743
Brand: Tocris Bioscience
SKU: 5715

Tocris Bioscience, part of Bio-Techne | Catalog # 5715

Citations (4)

COA / SDS

Negative allosteric modulator of mGlu7 receptors; brain penetrant

Key Product Details

Description:	Negative allosteric modulator of mGlu₇ receptors; brain penetrant
Chemical Name:	6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Purity:	≥98% (HPLC)
Molecular Weight:	269.34

View Full Technical Details for (±)-ADX 71743

Technical Data
Citations

Biological Activity for (±)-ADX 71743

(±)-ADX 71743 is a negative allosteric modulator at mGlu₇ (IC₅₀ = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Compound Libraries for (±)-ADX 71743

(±)-ADX 71743 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-ADX 71743

M. Wt	269.34
Formula	C₁₇H₁₉NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1431641-29-0
PubChem ID	53391766
InChi Key	CPKZCQHJDFSOJT-UHFFFAOYSA-N
Smiles	CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-ADX 71743

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.93	100
	ethanol	26.93	100

Preparing Stock Solutions for (±)-ADX 71743

The following data is based on the product molecular weight 269.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.56 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for (±)-ADX 71743

References are publications that support the biological activity of the product.

Tassin Phasic and tonic mGlu₇ receptor activity modulates the thalamocortical network. Front Neural Circuits 2016 PMID: 27199672
Klar Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 2015 PMID: 25972184