(±)-Bay K 8644

Name: (±)-Bay K 8644
Brand: Tocris Bioscience
SKU: 1544

Tocris Bioscience, part of Bio-Techne | Catalog # 1544

(1)

Citations (61)

COA / SDS

CaV1.x activator

Key Product Details

Chemical Name:	1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Purity:	≥98%
Molecular Weight:	356.3 kDa

View Full Technical Details for (±)-Bay K 8644

Technical Data
Citations / Reviews (1)

Biological Activity for (±)-Bay K 8644

(±)-Bay K 8644 is a L-type Ca²⁺ channel activator (EC₅₀ = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data for (±)-Bay K 8644

M. Wt	356.3 kDa
Formula	C₁₆H₁₅F₃N₂O₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	71145-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-Bay K 8644

Solubility

Soluble Soluble to 100 mM in ethanol and to 100 mM in DMSO

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References for (±)-Bay K 8644

References are publications that support the biological activity of the product.

Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell., 2008;3:568 PMID: 18983970
Sarkar et al. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ., 2009;16:46 PMID: 18636076
Greenberg et al. Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res., 1984;305:365 PMID: 6204725
Bourson et al. Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur.J.Pharmacol., 1989;160:339 PMID: 2469593