(±)-Eriodictyol

Name: (±)-Eriodictyol
Brand: Tocris Bioscience
SKU: 7199

Tocris Bioscience, part of Bio-Techne | Catalog # 7199

COA / SDS

Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling

Key Product Details

Description:	Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
Chemical Name:	2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	288.26

View Full Technical Details for (±)-Eriodictyol

Technical Data
Citations

Biological Activity for (±)-Eriodictyol

(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca²⁺ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H₂O₂-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

Technical Data for (±)-Eriodictyol

M. Wt	288.26
Formula	C₁₅H₁₂O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	4049-38-1
PubChem ID	11095
InChi Key	SBHXYTNGIZCORC-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-Eriodictyol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.83	100
	ethanol	14.41	50

Preparing Stock Solutions for (±)-Eriodictyol

The following data is based on the product molecular weight 288.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.35 mL	34.69 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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References for (±)-Eriodictyol

References are publications that support the biological activity of the product.

Rossato Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 2011 PMID: 21087598
Lou Eriodictyol protects against H₂O₂-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 2012 PMID: 22609376
Smith and Smith Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed