(E)-Capsaicin

Name: ( E )-Capsaicin
Brand: Tocris Bioscience
SKU: 0462
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0462

(1)

Citations (47)

COA / SDS

TRPV agonist

Key Product Details

Description:	TRPV agonist
Chemical Name:	(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Purity:	≥98% (HPLC)
Molecular Weight:	305.42

View Full Technical Details for (E)-Capsaicin

Technical Data
Citations / Reviews (1)

Biological Activity for (E)-Capsaicin

(E)-Capsaicin is a prototypic vanilloid receptor agonist (pEC₅₀ values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets.

Technical Data for (E)-Capsaicin

M. Wt	305.42
Formula	C₁₈H₂₇NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	404-86-4
PubChem ID	1548943
InChi Key	YKPUWZUDDOIDPM-SOFGYWHQSA-N
Smiles	COC1=C(O)C=CC(CNC(=O)CCCC\C=C\C(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (E)-Capsaicin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.27	50
	ethanol	15.27	50

Preparing Stock Solutions for (E)-Capsaicin

The following data is based on the product molecular weight 305.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.55 mL	32.74 mL	65.48 mL
2.5 mM	1.31 mL	6.55 mL	13.10 mL
5 mM	0.65 mL	3.27 mL	6.55 mL
25 mM	0.13 mL	0.65 mL	1.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (E)-Capsaicin

References are publications that support the biological activity of the product.

Ralevic Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 2001 PMID: 11672565
Hogaboam and Wallace Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur.J.Pharmacol. 1991 PMID: 1786800
Holzer Capsaicin-cellular targets, mechanism of actions, and selectivity for thin sensory neurons. Pharmacol.Rev. 1991 PMID: 1852779
Bevan and Szolcsani Sensory neuron-specific actions of capsaicin: mechanisms and application. TiPS 1990 PMID: 2203194