(±)-PPCC oxalate

Name: (±)-PPCC oxalate
Brand: Tocris Bioscience
SKU: 3870

Tocris Bioscience, part of Bio-Techne | Catalog # 3870

Citations (5)

COA / SDS

Selective sigma (σ) agonist (σ1> σ2)

Key Product Details

Description:	Selective sigma (σ) agonist (σ₁> σ₂)
Chemical Name:	(1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	469.53

View Full Technical Details for (±)-PPCC oxalate

Technical Data
Citations

Biological Activity for (±)-PPCC oxalate

(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ₁; also binds at σ₂ sites (K_i = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Compound Libraries for (±)-PPCC oxalate

(±)-PPCC oxalate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for (±)-PPCC oxalate

M. Wt	469.53
Formula	C₂₄H₂₉NO₃.C₂H₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1781628-91-8
PubChem ID	90488889
InChi Key	IGJDSEGFEVKASG-KLELIYFTSA-N
Smiles	CC(C=C3)=CC=C3[C@@]1(C(OC)=O)C[C@@H]1CN2CCC(C4=CC=CC=C4)(O)CC2.CC(C=C7)=CC=C7[C@]5([C@](OC)=O)C[C@H]5CN6CCC(C8=CC=CC=C8)(O)CC6.O=C(O)C(O)=O.O=C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-PPCC oxalate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.95	100
	ethanol	4.7	10

Preparing Stock Solutions for (±)-PPCC oxalate

The following data is based on the product molecular weight 469.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (±)-PPCC oxalate

References are publications that support the biological activity of the product.

Prezzavento A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 2008 PMID: 18261749
Antonini Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 2009 PMID: 19245662
Prezzavento Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 2007 PMID: 17328523