Docetaxel

Name: Docetaxel
Brand: Tocris Bioscience
SKU: 4056
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4056

(2)

Citations (27)

COA / SDS

Microtubule stabilizer

Key Product Details

Chemical Name:	[2aR-[2aα,4β,4aβ,6β,9α(αR,βS),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥99%
Molecular Weight:	807.88 kDa

View Full Technical Details for Docetaxel

Technical Data
Citations / Reviews (2)

Biological Activity for Docetaxel

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Technical Data for Docetaxel

M. Wt	807.88 kDa
Formula	C₄₃H₅₃NO₁₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	114977-28-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Docetaxel

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Docetaxel

References are publications that support the biological activity of the product.

Lyseng-Williamson and Fenton Docetaxel: a review of its use in metastatic breast cancer. Drugs, 2005;65:2513 PMID: 16296875
Ramaswamy and Puhalla Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc), 2006;42:265 PMID: 16703123