Dofetilide

Name: Dofetilide
Brand: Tocris Bioscience
SKU: 3757

Tocris Bioscience, part of Bio-Techne | Catalog # 3757

(1)

Citations (15)

COA / SDS

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Key Product Details

Chemical Name:	1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Purity:	≥99%

View Full Technical Details for Dofetilide

Technical Data
Citations / Reviews (1)

Biological Activity for Dofetilide

Dofetilide is a selective potassium channel blocker. Blocks K_V11.1 (hERG) channels; inhibits the rapid delayed-rectifier K⁺ current (I_Kr). Displays class III antiarrhythmic properties.

Technical Data for Dofetilide

Formula	C₁₉H₂₇N₃O₅S₂
Storage	Store at RT
Purity	≥99%
CAS Number	115256-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dofetilide

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Dofetilide

References are publications that support the biological activity of the product.

Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkil, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses. Journal of Cardiovascular Pharmacology, 2018;0(0):1533-4023. 2018 PMID: 29068807
Gwilt et al. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther., 1991;256:318 PMID: 1988662
Finlayson et al. [³H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K⁺ channel. Eur.J.Pharmacol., 2001;412:203 PMID: 11166283
Carmeliet Voltage- and time-dependent block of delayed K⁺ current in cardiac myocytes by dofet. J.Pharmacol.Exp.Ther., 1992;262:809 PMID: 1501123

Dofetilide

Tocris Bioscience, part of Bio-Techne | Catalog # 3757

Key Product Details

Biological Activity for Dofetilide

Technical Data for Dofetilide

Solubility for Dofetilide

Dilution Calculator

Reconstitution Calculator

References for Dofetilide

Product Documents for Dofetilide

COA

Certificate of Analysis

SDS

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