DR 4485 hydrochloride

Name: DR 4485 hydrochloride
Brand: Tocris Bioscience
SKU: 5005

Tocris Bioscience, part of Bio-Techne | Catalog # 5005

Citations (5)

COA / SDS

High affinity and selective 5-HT7 antagonist; orally bioavailable

Key Product Details

Description:	High affinity and selective 5-HT₇ antagonist; orally bioavailable
Chemical Name:	6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	491.88

View Full Technical Details for DR 4485 hydrochloride

Technical Data
Citations

Biological Activity for DR 4485 hydrochloride

DR 4485 hydrochloride is a high affinity and selective 5-HT₇ antagonist (pK_i = 8.14). Exhibits selectivity for 5-HT₇ over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT₇ receptor. Orally bioavailable.

Compound Libraries for DR 4485 hydrochloride

DR 4485 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DR 4485 hydrochloride

M. Wt	491.88
Formula	C₂₆H₂₈Cl₂N₂O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	402942-53-4
PubChem ID	90488996
InChi Key	QAERYGXKDZHTFR-UHFFFAOYSA-N
Smiles	ClC1=C2C(C3(CCCCN4CCC(C5=CC=C(Cl)C=C5)=CC4)CCC2)=C(NC3=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DR 4485 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.19	100

Preparing Stock Solutions for DR 4485 hydrochloride

The following data is based on the product molecular weight 491.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.17 mL	20.33 mL
5 mM	0.41 mL	2.03 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for DR 4485 hydrochloride

References are publications that support the biological activity of the product.

Medina Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J.Med.Chem. 2009 PMID: 19326916
Kikuchi New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg.Med.Chem.Lett. 2003 PMID: 12467617