dTAG-Biotin

Name: dTAG-Biotin
Brand: Tocris Bioscience
SKU: 7883

Tocris Bioscience, part of Bio-Techne | Catalog # 7883

COA / SDS

Affinity probe for mutant FKBP12F36V proteins

Key Product Details

Description:	Affinity probe for mutant FKBP12^F36V proteins
Chemical Name:	(R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	1094.33

View Full Technical Details for dTAG-Biotin

Technical Data
Citations

Biological Activity for dTAG-Biotin

dTAG-Biotin is an affinity probe for mutant FKBP12^F36V proteins. Comprises the ligand ortho-AP1867, selective for F36V single-point mutated FKBP12, joined by a PEG3 linker to biotin. It can be used for chemical biology studies such as proteomics, enrichment studies, dimerization experiments, and assay validation.

Technical Data for dTAG-Biotin

M. Wt	1094.33
Formula	C₅₆H₇₉N₅O₁₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	ZUFVYPUCFFRQTG-ZFJGIIHNSA-N
Smiles	CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(NCCOCCOCCOCCNC(CCCC[C@@H]4SC[C@@](N5)([H])[C@]4([H])NC5=O)=O)=O)CCC6=CC(OC)=C(C=C6)OC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for dTAG-Biotin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	109.43	100

Preparing Stock Solutions for dTAG-Biotin

The following data is based on the product molecular weight 1094.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.91 mL	4.57 mL	9.14 mL
5 mM	0.18 mL	0.91 mL	1.83 mL
10 mM	0.09 mL	0.46 mL	0.91 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

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Reconstitution Calculator

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References for dTAG-Biotin

References are publications that support the biological activity of the product.

Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585