dTRIM 24

Name: dTRIM 24
Brand: Tocris Bioscience
SKU: 6607

Tocris Bioscience, part of Bio-Techne | Catalog # 6607

Citations (1)

COA / SDS

TRIM24 Degrader (PROTAC®)

Key Product Details

Description:	TRIM24 Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1113.3

View Full Technical Details for dTRIM 24

Technical Data
Citations

Biological Activity for dTRIM 24

dTRIM 24 is a Degrader (PROTAC^®) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 μM. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for dTRIM 24

M. Wt	1113.3
Formula	C₅₅H₆₈N₈O₁₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2170695-14-2
PubChem ID	131954388
InChi Key	QUQTXFIMYFMULC-OGOZKGDESA-N
Smiles	CCCOC1=CC=CC(OC2=C(C=C3N(C(N(C3=C2)C)=O)C)NS(=O)(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)=CC=C4)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for dTRIM 24

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.27	20
	ethanol	22.27	20

Preparing Stock Solutions for dTRIM 24

The following data is based on the product molecular weight 1113.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	4.49 mL	22.46 mL	44.91 mL
1 mM	0.90 mL	4.49 mL	8.98 mL
2 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.09 mL	0.45 mL	0.90 mL

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References for dTRIM 24

References are publications that support the biological activity of the product.

Gechijian Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat.Chem.Biol. 2018 PMID: 29507391