DuP 697

Name: DuP 697
Brand: Tocris Bioscience
SKU: 1430

Tocris Bioscience, part of Bio-Techne | Catalog # 1430

Citations (18)

COA / SDS

Cyclooxygenase-2 (COX-2) inhibitor

Key Product Details

Description:	Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
Purity:	≥99% (HPLC)
Molecular Weight:	411.3

View Full Technical Details for DuP 697

Technical Data
Citations

Biological Activity for DuP 697

DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 (IC₅₀ values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.

Compound Libraries for DuP 697

DuP 697 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for DuP 697

M. Wt	411.3
Formula	C₁₇H₁₂BrFO₂S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	88149-94-4
PubChem ID	3177
InChi Key	AJFTZWGGHJXZOB-UHFFFAOYSA-N
Smiles	CS(=O)(=O)C1=CC=C(C=C1)C1=C(SC(Br)=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DuP 697

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.13	100

Preparing Stock Solutions for DuP 697

The following data is based on the product molecular weight 411.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.16 mL	24.31 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for DuP 697

References are publications that support the biological activity of the product.

Gierse Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 1995 PMID: 7832763
Rossoni Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 2002 PMID: 11906968
Gans Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 1990 PMID: 2366180