Dynasore

Name: Dynasore
Brand: Tocris Bioscience
SKU: 2897
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2897

(3)

Citations (141)

COA / SDS

Non-competitive dynamin inhibitor

Key Product Details

Description:	Non-competitive dynamin inhibitor
Chemical Name:	3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	322.32

View Full Technical Details for Dynasore

Technical Data
Citations / Reviews (3)

Biological Activity for Dynasore

Dynasore is a non-competitive reversible inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Dynasore blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells. Dynasore attenuates motor symptoms in an animal model of Parkinson's disease and in a cellular model of Alzheimer's disease it reduces tau protein aggregation and internalization.

Technical Data for Dynasore

M. Wt	322.32
Formula	C₁₈H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	304448-55-3
PubChem ID	5717066
InChi Key	NRQJUIHYFNUXFT-ZHACJKMWSA-N
Smiles	O=C(N/N=C/C3=CC(O)=C(O)C=C3)C2=CC1=CC=CC=C1C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dynasore

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.23	100

Preparing Stock Solutions for Dynasore

The following data is based on the product molecular weight 322.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.10 mL	6.21 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for Dynasore

References are publications that support the biological activity of the product.

Soares PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. J.Biol.Chem. 2021 PMID: 33831417
Feng Inhibition of dynamin-related protein 1 ameliorates the mitochondrial ultrastructure via PINK1 and Parkin in the mice model of Parkinson's disease. Eur.J.Pharmacol. 2021 PMID: 34146589
Macia Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell
Newton Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA
Thompson and McNiven Discovery of a new 'dynasore'. Nat.Chem.Biol. 2006 PMID: 16783339