EC 23

Name: EC 23
Brand: Tocris Bioscience
SKU: 4011

Tocris Bioscience, part of Bio-Techne | Catalog # 4011

Citations (26)

COA / SDS

Synthetic retinoid; induces differentiation of stem cells

Key Product Details

Description:	Synthetic retinoid; induces differentiation of stem cells
Chemical Name:	4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	332.44

View Full Technical Details for EC 23

Technical Data
Citations

Biological Activity for EC 23

EC 23 is a photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.

Licensing Information

Sold under license from Reinnervate Limited, patent pending

Compound Libraries for EC 23

EC 23 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for EC 23

M. Wt	332.44
Formula	C₂₃H₂₄O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	104561-41-3
PubChem ID	10314719
InChi Key	OQVLOWLEEHYBJH-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=CC(C#CC3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EC 23

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.24	100
	ethanol	1.66	5

Preparing Stock Solutions for EC 23

The following data is based on the product molecular weight 332.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.04 mL	30.08 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.50 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for EC 23

References are publications that support the biological activity of the product.

Barnard Synthetic retinoids: structure-activity relationships. Chemistry 2009 PMID: 19821467
Maltman Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 2009 PMID: 19381361
Christie Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 2008 PMID: 19082150