Edaglitazone

Name: Edaglitazone
Brand: Tocris Bioscience
SKU: 4784

Tocris Bioscience, part of Bio-Techne | Catalog # 4784

Citations (3)

COA / SDS

Potent and selective PPARγ agonist; antidiabetic

Key Product Details

Description:	Potent and selective PPARγ agonist; antidiabetic
Alternative Names:	R 483,BM 131258
Chemical Name:	5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	464.56

View Full Technical Details for Edaglitazone

Technical Data
Citations

Biological Activity for Edaglitazone

Edaglitazone is a potent and selective PPARγ agonist (EC₅₀ values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.

Compound Libraries for Edaglitazone

Edaglitazone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Edaglitazone

M. Wt	464.56
Formula	C₂₄H₂₀N₂O₄S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	213411-83-7
PubChem ID	9825701
InChi Key	HAAXAFNSRADSMK-UHFFFAOYSA-N
Smiles	CC(OC(C5=CC=CC=C5)=N4)=C4CCOC(C3=C2SC=C3)=CC=C2CC1C(NC(S1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Edaglitazone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Edaglitazone

The following data is based on the product molecular weight 464.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for Edaglitazone

References are publications that support the biological activity of the product.

Dietz Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 2012 PMID: 22489042
Fürnsinn Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br. J. Pharmacol. 1999 PMID: 10578125