EG 00229 trifluoroacetate

Name: EG 00229 trifluoroacetate
Brand: Tocris Bioscience
SKU: 6986

Tocris Bioscience, part of Bio-Techne | Catalog # 6986

Citations (6)

COA / SDS

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Key Product Details

Description:	Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Chemical Name:	N²-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	611.59

View Full Technical Details for EG 00229 trifluoroacetate

Technical Data
Citations

Biological Activity for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Compound Libraries for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EG 00229 trifluoroacetate

M. Wt	611.59
Formula	C₁₇H₁₉N₇O₅S₃.CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1210945-69-9
PubChem ID	45142253
InChi Key	ZYQBITUOSRZDTG-MERQFXBCSA-N
Smiles	O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EG 00229 trifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	61.16	100
	2eq. NaOH	61.16	100

Preparing Stock Solutions for EG 00229 trifluoroacetate

The following data is based on the product molecular weight 611.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.18 mL	16.35 mL
5 mM	0.33 mL	1.64 mL	3.27 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for EG 00229 trifluoroacetate

References are publications that support the biological activity of the product.

Daly Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 2020 PMID: 33082294
Jarvis Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 2010 PMID: 20151671