eIF4A i28

Name: eIF4A i28
Brand: Tocris Bioscience
SKU: 7810

Tocris Bioscience, part of Bio-Techne | Catalog # 7810

COA / SDS

eIF4A inhibitor

Key Product Details

Description:	eIF4A inhibitor
Chemical Name:	2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	416.43

View Full Technical Details for eIF4A i28

Technical Data
Citations

Biological Activity for eIF4A i28

eIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC₅₀ = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC₅₀ = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.

Licensing Information

Sold under license from the University of Arizona

Technical Data for eIF4A i28

M. Wt	416.43
Formula	C₂₄H₂₀N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2861994-92-3
PubChem ID	163198549
InChi Key	UDCAKLDMNJRQKW-UHFFFAOYSA-N
Smiles	CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for eIF4A i28

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.33	20

Preparing Stock Solutions for eIF4A i28

The following data is based on the product molecular weight 416.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.01 mL	60.03 mL	120.07 mL
1 mM	2.40 mL	12.01 mL	24.01 mL
2 mM	1.20 mL	6.00 mL	12.01 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

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Reconstitution Calculator

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References for eIF4A i28

References are publications that support the biological activity of the product.

Zerio Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 2021 PMID: 34676755