EIPA

Name: EIPA
Brand: Tocris Bioscience
SKU: 3378
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3378

(1)

Citations (31)

COA / SDS

Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)

Key Product Details

Description:	Inhibits TRPP3-mediated currents; also inhibits the Na⁺/H⁺ exchanger (NHE)
Alternative Names:	Ethylisopropyl amiloride
Chemical Name:	3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	299.76

View Full Technical Details for EIPA

Technical Data
Citations / Reviews (1)

Biological Activity for EIPA

EIPA is a TRPP3 channel inhibitor (IC₅₀ = 10.5 μM). Inhibits the Na⁺/H⁺ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).

Compound Libraries for EIPA

EIPA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EIPA

M. Wt	299.76
Formula	C₁₁H₁₈ClN₇O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1154-25-2
PubChem ID	1795
InChi Key	QDERNBXNXJCIQK-UHFFFAOYSA-N
Smiles	ClC1=C(N(C(C)C)CC)N=C(N)C(C(NC(N)=N)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EIPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.98	100

Preparing Stock Solutions for EIPA

The following data is based on the product molecular weight 299.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.36 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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Reconstitution Calculator

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References for EIPA

References are publications that support the biological activity of the product.

Horinouchi Functional role of Na⁺/H⁺ exchanger in Ca²⁺ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells. J.Pharm.Sci. 2008 PMID: 18678984
Dai Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 2007 PMID: 17804601