EMD 527040 hydrochloride

Name: EMD 527040 hydrochloride
Brand: Tocris Bioscience
SKU: 7508

Tocris Bioscience, part of Bio-Techne | Catalog # 7508

Citations (2)

COA / SDS

ανβ6 integrin inhibitor

Key Product Details

Description:	α_νβ₆ integrin inhibitor
Chemical Name:	N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	623.96

View Full Technical Details for EMD 527040 hydrochloride

Technical Data
Citations

Biological Activity for EMD 527040 hydrochloride

EMD 527040 hydrochloride is an inhibitor of integrin α_Vβ₆. EMD 527040 inhibits binding of α_Vβ₆ to fibronectin and attachment of cells expressing α_Vβ₆ to fibronectin (IC₅₀ values = 6 nM and 1.6 μM, respectively). EMD 527040 shows antifibrotic effects in an animal model of biliary fibrosis and is active in vivo.

Technical Data for EMD 527040 hydrochloride

M. Wt	623.96
Formula	C₂₉H₃₂Cl₂N₄O₅.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	BCWLDUVFBWVDQT-MRUATQDUSA-N
Smiles	ClC1=CC(C(CC(O)=O)NC(C(COCC2=CC=CC=C2)NC(CCCCNC3=NC=CC=C3)=O)=O)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EMD 527040 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	62.4	100
	ethanol	62.4	100

Preparing Stock Solutions for EMD 527040 hydrochloride

The following data is based on the product molecular weight 623.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.01 mL	16.03 mL
5 mM	0.32 mL	1.60 mL	3.21 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for EMD 527040 hydrochloride

References are publications that support the biological activity of the product.

Patsenker Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression. Gastroenterology 2008 PMID: 18538673