EMI 48

Name: EMI 48
Brand: Tocris Bioscience
SKU: 7424

Tocris Bioscience, part of Bio-Techne | Catalog # 7424

COA / SDS

Inhibitor of EGFR mutants

Key Product Details

Description:	Inhibitor of EGFR mutants
Chemical Name:	7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	348.4

View Full Technical Details for EMI 48

Technical Data
Citations

Biological Activity for EMI 48

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.

Technical Data for EMI 48

M. Wt	348.4
Formula	C₂₁H₂₀N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	34564-13-1
PubChem ID	15538560
InChi Key	PTAGJQADNFQMGR-UHFFFAOYSA-N
Smiles	CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EMI 48

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.97	20 with gentle warming

Preparing Stock Solutions for EMI 48

The following data is based on the product molecular weight 348.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.35 mL	71.76 mL	143.51 mL
1 mM	2.87 mL	14.35 mL	28.70 mL
2 mM	1.44 mL	7.18 mL	14.35 mL
10 mM	0.29 mL	1.44 mL	2.87 mL

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References for EMI 48

References are publications that support the biological activity of the product.

Saraon A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 2020 PMID: 32094923