EPPTB

Name: EPPTB
Brand: Tocris Bioscience
SKU: 4518
Rating: 2 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4518

(1)

Citations (5)

COA / SDS

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

Key Product Details

Description:	Trace amine 1 (TA₁) receptor antagonist; also displays inverse agonism
Chemical Name:	N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	378.39

View Full Technical Details for EPPTB

Technical Data
Citations / Reviews (1)

Biological Activity for EPPTB

EPPTB is a trace amine 1 (TA₁) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA₁ receptor than the rat and human TA₁ receptors (IC₅₀ values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA₁ receptor-mediated activation of an inwardly rectifying K⁺ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D₂ receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC₅₀ = 19 nM).

Compound Libraries for EPPTB

EPPTB is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EPPTB

M. Wt	378.39
Formula	C₂₀H₂₁F₃N₂O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1110781-88-8
PubChem ID	25175634
InChi Key	KLFVWQCQUXXLOU-UHFFFAOYSA-N
Smiles	O=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EPPTB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.84	100
	ethanol	37.84	100

Preparing Stock Solutions for EPPTB

The following data is based on the product molecular weight 378.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for EPPTB

References are publications that support the biological activity of the product.

Bradaia The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in DArgic neurons of the mesolimbic system. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19892733