ER 27319 maleate

Name: ER 27319 maleate
Brand: Tocris Bioscience
SKU: 2471

Tocris Bioscience, part of Bio-Techne | Catalog # 2471

(1)

Citations (1)

COA / SDS

Selective Syk kinase inhibitor

Key Product Details

Chemical Name:	10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Purity:	≥99%
Molecular Weight:	396.17 kDa

View Full Technical Details for ER 27319 maleate

Technical Data
Citations / Reviews (1)

Biological Activity for ER 27319 maleate

ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC₅₀ = 10 μM) and other related signaling events.

Technical Data for ER 27319 maleate

M. Wt	396.17 kDa
Formula	C₁₈H₂₀N₂O.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	1204480-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ER 27319 maleate

Solubility

Soluble Soluble to 75 mM in water and to 100 mM in DMSO

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References for ER 27319 maleate

References are publications that support the biological activity of the product.

A Tóth, E Zajta, K Csonka, C Vágvölgyi, MG Netea, A Gácser Specific pathways mediating inflammasome activation by Candida parapsilosis Sci Rep, 2017;7(0):43129. 2017 PMID: 28225025
Luskova and Draber Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des., 2004;10:1727 PMID: 15180535
Moriya et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA, 1997;94:12539