ERB 041

Name: ERB 041
Brand: Tocris Bioscience
SKU: 4276

Tocris Bioscience, part of Bio-Techne | Catalog # 4276

Citations (10)

COA / SDS

Potent ERβ agonist

Key Product Details

Description:	Potent ERβ agonist
Chemical Name:	7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity:	≥98% (HPLC)
Molecular Weight:	271.24

View Full Technical Details for ERB 041

Technical Data
Citations

Biological Activity for ERB 041

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC₅₀ values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for ERB 041

M. Wt	271.24
Formula	C₁₅H₁₀FNO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	524684-52-4
PubChem ID	5326893
InChi Key	FCXYSEXZEGPLGG-DHDCSXOGSA-N
Smiles	C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ERB 041

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.12	100
	ethanol	27.12	100

Preparing Stock Solutions for ERB 041

The following data is based on the product molecular weight 271.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for ERB 041

References are publications that support the biological activity of the product.

Malamas Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 2004 PMID: 15456246
Cvoro Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 2008 PMID: 18097065
Harris Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 2003 PMID: 14500559