ERB 041

Name: ERB 041
Brand: Tocris Bioscience
SKU: 4276

Tocris Bioscience, part of Bio-Techne | Catalog # 4276

Citations (10)

COA / SDS

Potent ERβ agonist

Key Product Details

Chemical Name:	7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity:	≥98%
Molecular Weight:	271.24 kDa

View Full Technical Details for ERB 041

Technical Data
Citations

Biological Activity for ERB 041

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC₅₀ values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Technical Data for ERB 041

M. Wt	271.24 kDa
Formula	C₁₅H₁₀FNO₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	524684-52-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ERB 041

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for ERB 041

References are publications that support the biological activity of the product.

GL Owens, KM Lawrence, TR Jackson, EJ Crosbie, BS Sayan, HC Kitchener, PA Townsend Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen Cancer Med, 2017;0(0):. 2017 PMID: 28109061
Malamas et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem., 2004;47:5021 PMID: 15456246
Harris et al. Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology, 2003;144:4241 PMID: 14500559
Cvoro et al. Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol., 2008;180:630 PMID: 18097065