Eticlopride hydrochloride

Name: Eticlopride hydrochloride
Brand: Tocris Bioscience
SKU: 1847
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1847

(1)

Citations (26)

COA / SDS

D2 and D3 antagonist (D3 > D2)

Key Product Details

Description:	D₂ and D₃ antagonist (D₃ > D₂)
Alternative Names:	(-)-Eticlopride
Chemical Name:	3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	377.31

View Full Technical Details for Eticlopride hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Eticlopride hydrochloride

Eticlopride hydrochloride is a selective dopamine D₂/D₃ receptor antagonist (K_i values are 0.50 and 0.16 nM respectively). Antipsychotic.

Technical Data for Eticlopride hydrochloride

M. Wt	377.31
Formula	C₁₇H₂₅ClN₂O₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	97612-24-3
PubChem ID	57266
InChi Key	HFJFXXDHVWLIKX-YDALLXLXSA-N
Smiles	O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Eticlopride hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	37.73	100

Preparing Stock Solutions for Eticlopride hydrochloride

The following data is based on the product molecular weight 377.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.50 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Eticlopride hydrochloride

References are publications that support the biological activity of the product.

Giuliani and Ferrari Involvement of DA receptors in the antipsychotic profile of (-) eticlopride. Physiol.Behav. 1997 PMID: 9108576
Claytor The effects of eticlopride and the selective D₃-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav. 2006 PMID: 16631246
Hall Some in vitro receptor binding properties of [³H]eticlopride, a novel substituted benzamide, selective for DA-D₂ receptors in the rat brain. Eur.J.Pharmacol. 1985 PMID: 4018125