Fendiline Hydrochloride

Name: Fendiline Hydrochloride
Brand: Tocris Bioscience
SKU: 6407

Tocris Bioscience, part of Bio-Techne | Catalog # 6407

Citations (2)

COA / SDS

Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker

Key Product Details

Description:	Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
Chemical Name:	N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	351.91

View Full Technical Details for Fendiline Hydrochloride

Technical Data
Citations

Biological Activity for Fendiline Hydrochloride

Fendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC₅₀ = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC₅₀ = 17 μM).

Compound Libraries for Fendiline Hydrochloride

Fendiline Hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Fendiline Hydrochloride

M. Wt	351.91
Formula	C₂₃H₂₅N.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	13636-18-5
PubChem ID	5702162
InChi Key	NJXWZWXCHBNOOG-UHFFFAOYSA-N
Smiles	CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fendiline Hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.19	100
	ethanol	7.04	20

Preparing Stock Solutions for Fendiline Hydrochloride

The following data is based on the product molecular weight 351.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.42 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for Fendiline Hydrochloride

References are publications that support the biological activity of the product.

van der Hoeven Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol.Cell.Biol. 2015 PMID: 23129805
Tripathi Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br.J.Pharmacol. 1993 PMID: 8485628