Fenobam

Name: Fenobam
Brand: Tocris Bioscience
SKU: 2386

Tocris Bioscience, part of Bio-Techne | Catalog # 2386

Citations (19)

COA / SDS

Potent and selective mGlu5 negative allosteric modulator (NAM)

Key Product Details

Description:	Potent and selective mGlu₅negative allosteric modulator (NAM)
Chemical Name:	N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
Purity:	≥99% (HPLC)
Molecular Weight:	266.69

View Full Technical Details for Fenobam

Technical Data
Citations

Biological Activity for Fenobam

Fenobam is a potent and selective non-competitive mGlu₅ negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu₅ constitutive activity in vitro (IC₅₀ = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu₅ receptor with K_d values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.

Compound Libraries for Fenobam

Fenobam is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Fenobam

M. Wt	266.69
Formula	C₁₁H₁₁N₄O₂Cl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	57653-26-6
PubChem ID	162834
InChi Key	DWPQODZAOSWNHB-UHFFFAOYSA-N
Smiles	CN1CC(=O)N=C1NC(=O)NC1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fenobam

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.67	100

Preparing Stock Solutions for Fenobam

The following data is based on the product molecular weight 266.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.75 mL	37.50 mL
5 mM	0.75 mL	3.75 mL	7.50 mL
10 mM	0.37 mL	1.87 mL	3.75 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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References for Fenobam

References are publications that support the biological activity of the product.

Liu Orthosteric and allosteric action of the C5a receptor antagonists Nature Structural & Molecular Biology 2018 PMID: 29867214
Kufahl Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine F1000Res. 2013 PMID: 24358885
Montana The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. J.Pharmacol.Exp.Ther. 2009 PMID: 19515968
Porter Description of a clinically validated anxiolytic with mGlu5 antagonist properties. Neuropharmacology
Porter Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J.Pharmacol.Exp.Ther. 2005 PMID: 16040814