FICZ

Name: FICZ
Brand: Tocris Bioscience
SKU: 5304

Tocris Bioscience, part of Bio-Techne | Catalog # 5304

Citations (4)

COA / SDS

High affinity aryl hydrocarbon receptor (AhR) agonist

Key Product Details

Description:	High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name:	5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity:	≥95% (HPLC)
Molecular Weight:	284.31

View Full Technical Details for FICZ

Technical Data
Citations

Biological Activity for FICZ

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (K_d = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data for FICZ

M. Wt	284.31
Formula	C₁₉H₁₂N₂O
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	172922-91-7
PubChem ID	1863
InChi Key	ZUDXFBWDXVNRKF-UHFFFAOYSA-N
Smiles	[H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FICZ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.11	25

Preparing Stock Solutions for FICZ

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.07 mL	70.35 mL	140.69 mL
1.25 mM	2.81 mL	14.07 mL	28.14 mL
2.5 mM	1.41 mL	7.03 mL	14.07 mL
12.5 mM	0.28 mL	1.41 mL	2.81 mL

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Reconstitution Calculator

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References for FICZ

References are publications that support the biological activity of the product.

Wincent The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 2009 PMID: 19054769
Moura-Alves AhR sensing of bacterial pigments regulates antibacterial defence. Nature 2014 PMID: 25119038
Rannug Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 1995 PMID: 8807817