Fisetin

Name: Fisetin
Brand: Tocris Bioscience
SKU: 5016

Tocris Bioscience, part of Bio-Techne | Catalog # 5016

Citations (13)

COA / SDS

Naturally occuring flavonoid and antioxidant; neuroprotective

Key Product Details

Description:	Naturally occuring flavonoid and antioxidant; neuroprotective
Chemical Name:	2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Purity:	≥97% (HPLC)
Molecular Weight:	286.24

View Full Technical Details for Fisetin

Technical Data
Citations

Biological Activity for Fisetin

Fisetin is a naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.

Technical Data for Fisetin

M. Wt	286.24
Formula	C₁₅H₁₀O₆
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	528-48-3
PubChem ID	5281614
InChi Key	XHEFDIBZLJXQHF-UHFFFAOYSA-N
Smiles	OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fisetin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.62	100
	ethanol	2.86	10

Preparing Stock Solutions for Fisetin

The following data is based on the product molecular weight 286.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.47 mL	34.94 mL
5 mM	0.70 mL	3.49 mL	6.99 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Fisetin

References are publications that support the biological activity of the product.

Lee Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 2005 PMID: 16037419
Maher ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 2011 PMID: 20952447
Adhami Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 2012 PMID: 22842629
Haddad Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 2010 PMID: 20574928
Lu Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 2005 PMID: 15689157