FPS ZM1

Tocris Bioscience, part of Bio-Techne | Catalog # 6237

(1)

Citations (11)

COA / SDS

High affinity antagonist of RAGE

Key Product Details

Description:	High affinity antagonist of RAGE
Chemical Name:	4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	327.85

View Full Technical Details for FPS ZM1

Technical Data
Citations / Reviews (1)

Biological Activity for FPS ZM1

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (K_i = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

Compound Libraries for FPS ZM1

FPS ZM1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for FPS ZM1

M. Wt	327.85
Formula	C₂₀H₂₂ClNO
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	945714-67-0
PubChem ID	24752728
InChi Key	XDFKWGIBQMHSOH-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FPS ZM1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.78	100
	ethanol	32.78	100

Preparing Stock Solutions for FPS ZM1

The following data is based on the product molecular weight 327.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.25 mL	30.50 mL
5 mM	0.61 mL	3.05 mL	6.10 mL
10 mM	0.31 mL	1.53 mL	3.05 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for FPS ZM1

References are publications that support the biological activity of the product.

Hong Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-beta Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus. Neurochem.Res. 2016 PMID: 26738988
Deane A multimodal RAGE-specific inhibitor reduces amyloid beta -mediated brain disorder in a mouse model of Alzheimer disease. J.Clin.Invest. 2012 PMID: 22406537