Furamidine dihydrochloride

Name: Furamidine dihydrochloride
Brand: Tocris Bioscience
SKU: 5202

Tocris Bioscience, part of Bio-Techne | Catalog # 5202

Citations (4)

COA / SDS

Selective PRMT1 inhibitor

Key Product Details

Chemical Name:	4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Purity:	≥98%

View Full Technical Details for Furamidine dihydrochloride

Technical Data
Citations

Biological Activity for Furamidine dihydrochloride

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC₅₀ = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Technical Data for Furamidine dihydrochloride

Formula	C₁₈H₁₆N₄O.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	55368-40-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Furamidine dihydrochloride

Solubility

Soluble Soluble to 50 mM in water and to 50 mM in DMSO

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References for Furamidine dihydrochloride

References are publications that support the biological activity of the product.

Yan et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem., 2014;57:2611 PMID: 24564570

Furamidine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5202

Key Product Details

Biological Activity for Furamidine dihydrochloride

Technical Data for Furamidine dihydrochloride

Solubility for Furamidine dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for Furamidine dihydrochloride

Product Documents for Furamidine dihydrochloride

COA

Certificate of Analysis

SDS

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