G-36

Tocris Bioscience, part of Bio-Techne | Catalog # 4759

COA / SDS

Selective GPER antagonist

Key Product Details

Description:	Selective GPER antagonist
Chemical Name:	(±)-(3aR,4S,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	412.33

View Full Technical Details for G-36

Technical Data
Citations

Biological Activity for G-36

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC₅₀ = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Compound Libraries for G-36

G-36 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for G-36

M. Wt	412.33
Formula	C₂₂H₂₂BrNO₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1392487-51-2
PubChem ID	73755224
InChi Key	QTOCPACSSHFGOY-ZCCHDVMBSA-N
Smiles	BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC(C(C)C)=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G-36

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.23	100

Preparing Stock Solutions for G-36

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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Reconstitution Calculator

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References for G-36

References are publications that support the biological activity of the product.

Dennis Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J.Steroid Biochem.Mol.Biol. 2011 PMID: 21782022
Prossnitz and Barton The G-protein-coupled estrogen receptor GPER in health and disease. Nat.Rev.Endocrinol. 2011 PMID: 21844907