G 5555

Name: G 5555
Brand: Tocris Bioscience
SKU: 6051

Tocris Bioscience, part of Bio-Techne | Catalog # 6051

Citations (3)

COA / SDS

High affinity group I PAK inhibitor

Key Product Details

Chemical Name:	8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
Purity:	≥98%

View Full Technical Details for G 5555

Technical Data
Citations

Biological Activity for G 5555

G 5555 is a high affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (K_i = 3.7 nM; pMEK IC₅₀ = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.

Technical Data for G 5555

Formula	C₂₅H_25ClN₆O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1648863-90-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G 5555

Solubility

Soluble Soluble to 100 mM in 1eq. HCl and to 20 mM in DMSO with gentle warming

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References for G 5555

References are publications that support the biological activity of the product.

Ndubaku et al. Design of selective PAK1 inhibitor G-5555: improving properties by employing an unorthodox low-pK a polar moiety. ACS Med.Chem.Lett., 2015;6:1241 PMID: 26713112

G 5555

Tocris Bioscience, part of Bio-Techne | Catalog # 6051

Key Product Details

Biological Activity for G 5555

Technical Data for G 5555

Solubility for G 5555

Dilution Calculator

Reconstitution Calculator

References for G 5555

Product Documents for G 5555

COA

Certificate of Analysis

SDS

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