Gap 26

Name: Gap 26
Brand: Tocris Bioscience
SKU: 1950

Tocris Bioscience, part of Bio-Techne | Catalog # 1950

Citations (66)

COA / SDS

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

Discontinued Product

1950 has been discontinued. View all Gap Channel Blockers products.

Key Product Details

Description:	Gap junction blocker; inhibits smooth muscle contraction and IP₃-mediated ATP release
Purity:	≥95% (HPLC)
Molecular Weight:	1550.79

View Full Technical Details for Gap 26

Technical Data
Citations

Biological Activity for Gap 26

Gap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC₅₀ = 28.4 μM). Also inhibits IP₃-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Technical Data for Gap 26

M. Wt	1550.79
Formula	C₇₀H₁₀₇N₁₉O₁₉S
Single Letter Sequence	VCYDKSFPISHVR
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	197250-15-0
PubChem ID	25088334
InChi Key	FDPIMWZHGJNESB-VCSXYVMHSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Gap 26

References are publications that support the biological activity of the product.

Chaytor Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 1997 PMID: 9288678
Braet Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 2003 PMID: 12526886

Gap 26

Tocris Bioscience, part of Bio-Techne | Catalog # 1950

Key Product Details

Biological Activity for Gap 26

Technical Data for Gap 26

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Gap 26

Product Documents for Gap 26

COA

Certificate of Analysis

SDS

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