Gap19

Name: Gap19
Brand: Tocris Bioscience
SKU: 5353

Tocris Bioscience, part of Bio-Techne | Catalog # 5353

Citations (23)

COA / SDS

Cx43 hemichannel blocker

Key Product Details

Description:	Cx43 hemichannel blocker
Purity:	≥95% (HPLC)
Molecular Weight:	1161.45

View Full Technical Details for Gap19

Technical Data
Citations

Biological Activity for Gap19

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Technical Data for Gap19

M. Wt	1161.45
Formula	C₅₅H₉₆N₁₄O₁₃
Single Letter Sequence	KQIEIKKFK
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1507930-57-5
PubChem ID	91691126
InChi Key	IEAKEKFIXUZWEH-PKMKMBMKSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gap19

Solubility

Soluble to 2mg/ml in water

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References for Gap19

References are publications that support the biological activity of the product.

Wang Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 2013 PMID: 23184389
Abudara The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 2014 PMID: 25374505
Boengler Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 PMID: 23760924