Gastrin I (human)

Name: Gastrin I (human)
Brand: Tocris Bioscience
SKU: 3006
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3006

(1)

Citations (47)

COA / SDS

Selective CCK2 agonist

Key Product Details

Purity:	≥95%
Molecular Weight:	2098.22 kDa

View Full Technical Details for Gastrin I (human)

Technical Data
Citations / Reviews (1)

Biological Activity for Gastrin I (human)

Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC₅₀ values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.

Technical Data for Gastrin I (human)

M. Wt	2098.22 kDa
Formula	C₉₇H₁₂₄N₂₀O₃₁S
Storage	Store at -20°C
Purity	≥95%
CAS Number	10047-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gastrin I (human)

Solubility

Soluble Soluble to 1 mg/ml in 1% Ammonia with sonication

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References for Gastrin I (human)

References are publications that support the biological activity of the product.

MI Capurro, LK Greenfield, A Prashar, S Xia, M Abdullah, H Wong, XZ Zhong, N Bertaux-Sk, J Chakrabart, I Siddiqui, C O'Brien, X Dong, L Robinson, RM Peek, DJ Philpott, Y Zavros, M Helmrath, NL Jones VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1 Nat Microbiol, 2019;0(0):. 2019 PMID: 31110360
T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells Cell Mol Gastroenterol Hepatol, 2019;7(1):73-91. 2019 PMID: 30510992
Noble et al. International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev., 1999;51:745 PMID: 10581329
Blandizzi et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol., 1999;373:71 PMID: 10408253
Bartfeld et al. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology, 2015;148:126 PMID: 25307862
Sato et al. SnapShot: Growing Organoids from Stem Cells. Cell, 2015;161:1700 PMID: 26091044
Mahe et al. Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol., 2014;3:217 PMID: 25105065