GKA 50

Name: GKA 50
Brand: Tocris Bioscience
SKU: 5133

Tocris Bioscience, part of Bio-Techne | Catalog # 5133

Citations (1)

COA / SDS

Glucokinase activator

Key Product Details

Description:	Glucokinase activator
Chemical Name:	6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	464.51

View Full Technical Details for GKA 50

Technical Data
Citations

Biological Activity for GKA 50

GKA 50 is a potent glucokinase activator (EC₅₀ = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

Compound Libraries for GKA 50

GKA 50 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GKA 50

M. Wt	464.51
Formula	C₂₆H₂₈N₂O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	851884-87-2
PubChem ID	11340230
InChi Key	OCBMECSFDVUYQN-ROUUACIJSA-N
Smiles	O=C(NC3=NC=C(C(O)=O)C=C3)C1=CC(O[C@@H](C)COC)=CC(O[C@@H](C)CC2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GKA 50

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.45	100

Preparing Stock Solutions for GKA 50

The following data is based on the product molecular weight 464.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for GKA 50

References are publications that support the biological activity of the product.

Johnson Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells. Biochem.Soc.Trans. 2007 PMID: 17956314
Coope Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 2006 PMID: 16921397