GNE 9278

Name: GNE 9278
Brand: Tocris Bioscience
SKU: 6369

Tocris Bioscience, part of Bio-Techne | Catalog # 6369

Citations (2)

COA / SDS

Positive allosteric modulator of NMDA receptors; acts in transmembrane domain

Key Product Details

Description:	Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
Chemical Name:	4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	429.54

View Full Technical Details for GNE 9278

Technical Data
Citations

Biological Activity for GNE 9278

GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC₅₀ values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca²⁺ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.

Compound Libraries for GNE 9278

GNE 9278 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GNE 9278

M. Wt	429.54
Formula	C₂₁H₂₇N₅O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	901230-11-3
PubChem ID	22432385
InChi Key	OKXCVUICUUOADN-UHFFFAOYSA-N
Smiles	OC(N1C2=NC(CCC)=N1)=C(C(C)=N2)N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GNE 9278

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.95	100

Preparing Stock Solutions for GNE 9278

The following data is based on the product molecular weight 429.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for GNE 9278

References are publications that support the biological activity of the product.

Wang A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 2017 PMID: 28457974