Go 6976

Biological Activity for Go 6976

Technical Data for Go 6976

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Go 6976

References for Go 6976

References are publications that support the biological activity of the product.

• Uhlenbrock F, Hagemann-Jensen M, Kehlet S, Andresen L, Pastorekova S, Skov S The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. J Immunol, 2014;193(4):1654-65. 2014 PMID: 25024379
• RD Macarie, M Vadana, L Ciortan, MM Tucureanu, A Ciobanu, D Vinereanu, I Manduteanu, M Simionescu, E Butoi The expression of MMP-1 and MMP-9 is up-regulated by smooth muscle cells after their cross-talk with macrophages in high glucose conditions J. Cell. Mol. Med., 2018;0(0):. 2018 PMID: 29992758
• Stolz A, Vogel C, Schneider V et al. Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res 2009-05-01 PMID: 19366805
• Martiny-Baron et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole G� 6976 J.Biol.Chem., 1993;268:9194 PMID: 8486620
• Rennecke et al. Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines. Eur.J.Biochem., 1996;242:428 PMID: 8973662
• Behrens et al. Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J.Neurochem., 1999;72:919 PMID: 10037462
• Grandage et al. Go6976 is a potent inhibitor of JAK2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. Br.J.Haematol., 2006;135:303 PMID: 16956345