GPBAR-A

Tocris Bioscience, part of Bio-Techne | Catalog # 4478

COA / SDS

GPBA receptor (TGR5) agonist

Key Product Details

Description:	GPBA receptor (TGR5) agonist
Chemical Name:	4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	484.37

View Full Technical Details for GPBAR-A

Technical Data
Citations

Biological Activity for GPBAR-A

GPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.

Technical Data for GPBAR-A

M. Wt	484.37
Formula	C₂₃H₁₅F₇N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	877052-79-4
PubChem ID	11656002
InChi Key	ZIXNJVGTAXRKAP-UHFFFAOYSA-N
Smiles	O=C(CO3)N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)CC1=C3N=CC=C1C2=C(F)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GPBAR-A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.44	100
	ethanol	9.69	20

Preparing Stock Solutions for GPBAR-A

The following data is based on the product molecular weight 484.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.32 mL	20.65 mL
5 mM	0.41 mL	2.06 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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Reconstitution Calculator

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References for GPBAR-A

References are publications that support the biological activity of the product.

Keitel The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009 PMID: 19582812
Parker Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. Br.J.Pharmacol. 2012 PMID: 21718300