GR 73632

Name: GR 73632
Brand: Tocris Bioscience
SKU: 1669

Tocris Bioscience, part of Bio-Techne | Catalog # 1669

Citations (30)

COA / SDS

Potent and selective NK1 agonist

Key Product Details

Description:	Potent and selective NK₁ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	766.01

View Full Technical Details for GR 73632

Technical Data
Citations

Biological Activity for GR 73632

GR 73632 is a potent and selective tachykinin NK₁ receptor agonist (EC₅₀ = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 73632

M. Wt	766.01
Formula	C₄₀H₅₉N₇O₆S
Single Letter Sequence	FFPLM (Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	133156-06-6
PubChem ID	119599
InChi Key	HQKPTSSZOJLFBZ-LJADHVKFSA-N
Smiles	[H]N([C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GR 73632

Solubility

Soluble to 1mg/ml in water

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References for GR 73632

References are publications that support the biological activity of the product.

Sheahan The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 2021 PMID: 33051347
Meini GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK₁ receptor in the rat urinary bladder. Neuropeptides 1995 PMID: 7538205
Sakurada Spinal actions of GR73632, a novel tachykinin NK₁ receptor agonist. Peptides 1999 PMID: 10422886
Hall and Morton Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 1991 PMID: 1719888