GRP (human)

Name: GRP (human)
Brand: Tocris Bioscience
SKU: 1789

Tocris Bioscience, part of Bio-Techne | Catalog # 1789

Citations (4)

COA / SDS

Endogenous GRP receptor agonist

Key Product Details

Description:	Endogenous GRP receptor agonist
Alternative Names:	Gastrin-releasing peptide (human)
Purity:	≥95% (HPLC)
Molecular Weight:	2859.4

View Full Technical Details for GRP (human)

Technical Data
Citations

Biological Activity for GRP (human)

GRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Technical Data for GRP (human)

M. Wt	2859.4
Formula	C₁₃₀H₂₀₄N₃₈O₃₁S₂
Single Letter Sequence	VPLPAGGGTVLTKMYPRGNHWAVGHLM (Modifications: Met-27 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	93755-85-2
PubChem ID	16143985
InChi Key	PUBCCFNQJQKCNC-XKNFJVFFSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GRP (human)

Solubility

Soluble to 1mg/ml in water

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References for GRP (human)

References are publications that support the biological activity of the product.

Woodruff Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 1996 PMID: 8602736
Dudai Neurobiology: Fear thou not. Nature 2003 PMID: 12540884
Shumyatsky Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002 PMID: 12526815
Benya Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 1995 PMID: 7838118