GS 143

Name: GS 143
Brand: Tocris Bioscience
SKU: 5636

Tocris Bioscience, part of Bio-Techne | Catalog # 5636

Citations (4)

COA / SDS

β-TrCP1 ligase inhibitor

Key Product Details

Description:	β-TrCP1 ligase inhibitor
Chemical Name:	4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	466.46

View Full Technical Details for GS 143

Technical Data
Citations

Biological Activity for GS 143

GS 143 is a β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC₅₀ = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.

Compound Libraries for GS 143

GS 143 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GS 143

M. Wt	466.46
Formula	C₂₈H₁₉FN₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	916232-21-8
PubChem ID	11963988
InChi Key	IZPMWFSVTDOCDI-QJOMJCCJSA-N
Smiles	FC1=CC=CC=C1C2=CC=C(/C=C3C(CC4=CC=CC=C4)=NN(C5=CC=C(C(O)=O)C=C5)C\3=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GS 143

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.65	100

Preparing Stock Solutions for GS 143

The following data is based on the product molecular weight 466.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.72 mL	21.44 mL
5 mM	0.43 mL	2.14 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for GS 143

References are publications that support the biological activity of the product.

Hirose GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem.Biophys.Res.Comm. 2008 PMID: 18656449
Nakajima A novel small-molecule inhibitor of NF-κB signaling. Biochem.Biophys.Res.Comm. 2008 PMID: 18275844