GS 441524

Name: GS 441524
Brand: Tocris Bioscience
SKU: 7227

Tocris Bioscience, part of Bio-Techne | Catalog # 7227

COA / SDS

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide

Key Product Details

Description:	Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide
Chemical Name:	(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	291.27

View Full Technical Details for GS 441524

Technical Data
Citations

Biological Activity for GS 441524

GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC₅₀ values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC₅₀ = 1.1 μM).

Compound Libraries for GS 441524

GS 441524 is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GS 441524

M. Wt	291.27
Formula	C₁₂H₁₃N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1191237-69-0
PubChem ID	44468216
InChi Key	BRDWIEOJOWJCLU-LTGWCKQJSA-N
Smiles	OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GS 441524

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.13	100

Preparing Stock Solutions for GS 441524

The following data is based on the product molecular weight 291.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.17 mL	34.33 mL
5 mM	0.69 mL	3.43 mL	6.87 mL
10 mM	0.34 mL	1.72 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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Reconstitution Calculator

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References for GS 441524

References are publications that support the biological activity of the product.

Cho Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Bioorg.Med.Chem.Lett. 2012 PMID: 22446091
Agostini Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease mBio. 2018 PMID: 29511076