GSK 2795039

Name: GSK 2795039
Brand: Tocris Bioscience
SKU: 6848

Tocris Bioscience, part of Bio-Techne | Catalog # 6848

Citations (3)

COA / SDS

NADPH oxidase 2 (NOX2) inhibitor

Key Product Details

Description:	NADPH oxidase 2 (NOX2) inhibitor
Chemical Name:	N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	450.56

View Full Technical Details for GSK 2795039

Technical Data
Citations

Biological Activity for GSK 2795039

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC₅₀ value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

Compound Libraries for GSK 2795039

GSK 2795039 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2795039

M. Wt	450.56
Formula	C₂₃H₂₆N₆O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1415925-18-6
PubChem ID	71090129
InChi Key	FMWVTCZKCXPKFW-UHFFFAOYSA-N
Smiles	CC(N1C=C(C2=CC=C3CCN(C3=C2)C)C4=C(C=CN=C14)NS(=O)(C5=NN(C=C5)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2795039

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.06	100

Preparing Stock Solutions for GSK 2795039

The following data is based on the product molecular weight 450.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.19 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for GSK 2795039

References are publications that support the biological activity of the product.

Hirano Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor. Antioxid.Redox.Signal. 2015 PMID: 26135714