GSK 319347A

Name: GSK 319347A
Brand: Tocris Bioscience
SKU: 5672

Tocris Bioscience, part of Bio-Techne | Catalog # 5672

Citations (2)

COA / SDS

Potent and selective IKKε inhibitor

Key Product Details

Description:	Potent and selective IKKε inhibitor
Chemical Name:	5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	469.53

View Full Technical Details for GSK 319347A

Technical Data
Citations

Biological Activity for GSK 319347A

GSK 319347A is a potent and selective IKKε inhibitor (pIC₅₀ = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

Compound Libraries for GSK 319347A

GSK 319347A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 319347A

M. Wt	469.53
Formula	C₂₂H₁₉N₃O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	862812-98-4
PubChem ID	11626927
InChi Key	LDTAHRLHGHFHKP-UHFFFAOYSA-N
Smiles	CS(C1=CC=CC=C1COC2=C(C#N)SC(N3C4=CC(OC)=C(OC)C=C4N=C3)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 319347A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.95	100

Preparing Stock Solutions for GSK 319347A

The following data is based on the product molecular weight 469.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for GSK 319347A

References are publications that support the biological activity of the product.

Bamborough 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 2006 PMID: 16997559