GSK 3787

Name: GSK 3787
Brand: Tocris Bioscience
SKU: 3961

Tocris Bioscience, part of Bio-Techne | Catalog # 3961

Citations (15)

COA / SDS

Potent and selective PPARδ antagonist

Key Product Details

Description:	Potent and selective PPARδ antagonist
Chemical Name:	4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	392.78

View Full Technical Details for GSK 3787

Technical Data
Citations

Biological Activity for GSK 3787

GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC₅₀ = 6.6). Displays no measurable affinity for PPARα or PPARγ in vitro (pIC₅₀< 5).

Compound Libraries for GSK 3787

GSK 3787 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 3787

M. Wt	392.78
Formula	C₁₅H₁₂ClF₃N₂O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	188591-46-0
PubChem ID	2800647
InChi Key	JFUIMTGOQCQTPF-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(Cl)C=C2)NCCS(C1=CC=C(C(F)(F)F)C=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 3787

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.28	100

Preparing Stock Solutions for GSK 3787

The following data is based on the product molecular weight 392.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.73 mL	25.46 mL
5 mM	0.51 mL	2.55 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for GSK 3787

References are publications that support the biological activity of the product.

Palkar Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787. Mol.Pharmacol. 2010 PMID: 20516370
Shearer Identification and characterization of 4-chloro-N(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J.Med.Chem. 2010 PMID: 20128594